An RNA molecule is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes. RNA and DNA are nucleic acids, but RNA differs from DNA in several key aspects: it is typically single-stranded, contains ribose as its sugar (instead of deoxyribose in DNA), and uses uracil as a base (instead of thymine in DNA).
Types of RNA: There are several types of RNA, including messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), and non-coding RNAs such as microRNA (miRNA) and long non-coding RNA (lncRNA). Each type plays a specific role in the cell.
RNA Structure: RNA's single-stranded nature allows it to fold into complex three-dimensional structures, which are critical for its function. These structures are stabilized by base pairing, often involving non-canonical base pairs beyond the standard Watson-Crick pairing.
Transcription: RNA is synthesized from a DNA template during transcription, a process carried out by enzymes called RNA polymerases.
RNA Processing: In eukaryotes, RNA transcripts often undergo processing steps before they can function, including splicing (removal of introns), capping (addition of a modified guanine nucleotide to the 5' end), and polyadenylation (addition of a poly(A) tail to the 3' end).
Translation: mRNA carries genetic information from DNA to ribosomes, where it is translated into proteins. tRNAs are involved in bringing amino acids to the ribosome during translation.
RNA World Hypothesis: The RNA world hypothesis suggests that RNA, not DNA, was the primary form of genetic material in early life. RNA can store genetic information and catalyze chemical reactions.
RNA Interference: Small RNA molecules, like siRNA and miRNA, can regulate gene expression through RNA interference.
RNA is crucial for many biological processes and is a dynamic and versatile molecule with diverse functions.
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